Rapid, noninvasive diagnosis of visceral leishmaniasis in India: comparison of two immunochromatographic strip tests for detection of anti-K39 antibody

Sundar, Shyam ; Maurya, Radheshyam ; Singh, Rakesh K. ; Bharti, K. ; Chakravarty, Jaya ; Parekh, Ashish ; Rai, Madhukar ; Kumar, Kailash ; Murray, Henry W. (2006) Rapid, noninvasive diagnosis of visceral leishmaniasis in India: comparison of two immunochromatographic strip tests for detection of anti-K39 antibody Journal of Clinical Microbiology, 44 (1). pp. 251-256. ISSN 0095-1137

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Official URL: http://jcm.asm.org/cgi/content/abstract/44/1/251

Related URL: http://dx.doi.org/10.1128/JCM.44.1.251-253.2006

Abstract

Used with blood or serum, a new anti-K39 antibody immunochromatographic strip test (IT-Leish; DiaMed AG) proved sensitive (range, 99 to 100%) and specific (range, 95 to 100%) for the noninvasive serodiagnosis of visceral leishmaniasis in India. Used with serum, the IT-Leish test and the existing Kalazar Detect test (InBios International, Inc.) yielded comparable results for symptomatic infection and identified apparent subclinical infection in 15 to 32% of healthy residents in a region where visceral leishmaniasis is highly endemic.

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