Immunomodulatory activity of met-enkephalin and its two potent analogs

Bajpai, K. ; Singh, V. K. ; Agarwal, S. S. ; Dhawan, V. C. ; Naqvi, T. ; Haq, W. ; Mathur, K. B. (1995) Immunomodulatory activity of met-enkephalin and its two potent analogs International Journal of Immunopharmacology, 17 (3). pp. 207-212. ISSN 0192-0561

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The effects of Met-enkephalin (Met-Enk), a delta receptor binding opioid peptide, and its more stable synthetic analogs, Tyr-D-Ala-Gly-MePhe-Met-NHC3H7-iso (1), Tyr-D-Ala-Gly-MePhe-Gly-NHC3H7-iso (2) and Tyr-D-Ala-Gly-McPhe-Gly-NHCH2C6H5 (3), on human T-cell transformation and natural killer (NK) cell cytotoxicity have been evaluated. Analogs 1 and 2 have been found to be as potent as Met-Enk in stimulating T-cell transformation and augmenting NK cell cytotoxicity. Analog 3 had no effect on T-cell transformation and NK cell cytotoxicity. Proliferative response was measured by 3H-thymidine uptake after 5 days of incubation. The kinetics of the T-cell transformation response (peak 5th day) is similar to those for in vitro T-cell responses to specific antigens rather than via polyclonal activation.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Enkephalin; Immunomodulator; NK Cells; Synthetic Analogs; T-cell Transformation
ID Code:71
Deposited On:16 Sep 2010 10:44
Last Modified:12 May 2011 03:53

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