Membrane organization and function of the serotonin1A receptor

Kalipatnapu, Shanti ; Chattopadhyay, Amitabha (2007) Membrane organization and function of the serotonin1A receptor Cellular and Molecular Neurobiology, 27 (8). pp. 1097-1116. ISSN 0272-4340

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(1) The serotonin1A receptor is a G-protein coupled receptor involved in several cognitive, behavioral, and developmental functions. It binds the neurotransmitter serotonin and signals across the membrane through its interactions with heterotrimeric G-proteins. (2) Lipid-protein interactions in membranes play an important role in the assembly, stability, and function of membrane proteins. The role of membrane environment in serotonin1A receptor function is beginning to be addressed by exploring the consequences of lipid manipulations on the ligand binding and G-protein coupling of serotonin1A receptors, the ability to functionally solubilize the serotonin1A receptor, and the factors influencing the membrane organization of the serotonin1A receptor. (3) Recent developments involving the application of detergent-based and detergent-free approaches to understand the membrane organization of the serotonin1A receptor under conditions of ligand activation and modulation of membrane lipid content, with an emphasis on membrane cholesterol, are described.

Item Type:Article
Source:Copyright of this article belongs to Springer-Verlag.
Keywords:Serotonin Receptor; G-protein Coupling; Solubilization; Membrane Lipid Environment; Cholesterol; Detergent Insolubility; Detergent-free Approach
ID Code:6983
Deposited On:26 Oct 2010 04:50
Last Modified:16 May 2016 17:14

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