Chakraborty, T. K. (1996) Studies directed towards the development of cyclic peptide-based analogs of macrolide immunosuppressants Pure and Applied Chemistry, 68 (3). pp. 565-568. ISSN 0033-4545
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Official URL: http://www.iupac.org/publications/pac/68/3/0565/
Related URL: http://dx.doi.org/10.1351/pac199668030565
Abstract
A simple strategy for the facile synthesis of cyclic rapamycinpeptide hybrids is developed and the affinities of these synthetic hybrids for FKBPl2 are evaluated. The results prompted to undertake a systematic study on the optimum length of the peptide cassette required for locking the binding domain of rapamycin in the specific conformation as present in i t s FKBP12-bound crystal structure. This led to the development of a high affinity FKBPl2 ligand.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to International Union of Pure and Applied Chemistry. |
| ID Code: | 69593 |
| Deposited On: | 14 Nov 2011 03:50 |
| Last Modified: | 14 Nov 2011 03:50 |
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