Delivery in vivo of 14-deoxy-11-oxoandrographolide, an antileishmanial agent, by different drug carriers

Lala, S. ; Nandy, A. K. ; Mahato, S. B. ; Basu, M. K. (2003) Delivery in vivo of 14-deoxy-11-oxoandrographolide, an antileishmanial agent, by different drug carriers Indian Journal of Biochemistry and Biophysics, 40 (3). pp. 169-174. ISSN 0301-1208

[img]
Preview
PDF - Publisher Version
147kB

Official URL: http://nopr.niscair.res.in/bitstream/123456789/375...

Abstract

An antileishmanial compound, 14-deoxy-11-oxo-andrographolide, a derivative of andrographlide, isolated from the Indian medicinal plant Andrographis paniculata was evaluated for efficacy in free form and in different vesicular delivery modes on hamster model of Leishmaniasis. The subcutaneous injection of free drug reduced the spleen parasite load by 39%, whereas for drug incorporated in liposomes, niosomes and microspheres, reductions in the parasite load were 78%, 91% and 59%, respectively. Moreover, the drug in various delivery modes, particularly in liposomal and niosomal forms, showed no apparent immediate toxicity. Although an inverse linear relationship between the size of carriers and per cent efficacy in reduction of spleen parasite load was established, involvement of other factors such as drug release profiles or rates remains an open question. Because of greater efficacy and lesser toxicity, liposomal, niosomal and possibly microsphere-incorporated 14-deoxy-11-oxo-andrographolide might have clinical application to combat visceral Leishmaniasis.

Item Type:Article
Source:Copyright of this article belongs to National Institute of Science Communication and Information Resources.
Keywords:Andrographis paniculata; Antileishmanial Compound; 14-deoxy-11-oxoandrographolide; Drug Carriers; in vivo Delivery; Liposomes; Microspheres; Niosomes
ID Code:69516
Deposited On:12 Nov 2011 03:46
Last Modified:18 May 2016 15:53

Repository Staff Only: item control page