An unusual cause of paraparesis in a patient on chronic steroid therapy

Gupta, R. ; Kumar, A. N. ; Gupta, V. ; Madhavan, Sethu M. ; Sharma, S. K. (2007) An unusual cause of paraparesis in a patient on chronic steroid therapy Journal of Spinal Cord Medicine, 30 (1). pp. 67-69. ISSN 1079-0268

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Background/Objective: Spinal epidural lipomatosis is the excessive deposition of unencapsulated fat in the epidural space. This is a rare disorder often associated with high levels of endogenous steroids or the administration of exogenous steroids. Case Description: A 32-year-old man with congenital kyphosis treated with prednisolone daily for 5 months for interstitial lung disease developed compressive myelopathy. Findings: Magnetic resonance imaging showed congenital kyphosis along with epidural lipomatosis compressing the cord. Cessation of steroid therapy was associated with improvement in the symptoms. Conclusions: Spinal epidural lipomatosis is a rare side effect of chronic steroid therapy that may occur with relatively short-term, low-dose regimens. In patients with congenital vertebral anomalies, spinal fat deposition may worsen the neurological status in an already compromised cord. Discontinuation of steroid therapy is beneficial; some patients may require surgical intervention for decompression.

Item Type:Article
Source:Copyright of this article belongs to American Paraplegia Society.
Keywords:Lipomatosis; Spinal Epidural; Steroid Therapy Complications; Kyphosis; Congenital; Prednisolone; Myelopathy; Compressive; Paraparesis; Cushing Syndrome
ID Code:69364
Deposited On:10 Nov 2011 10:14
Last Modified:10 Nov 2011 10:14

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