M150 modulates the costimulatory signals delivered by B cells to T cells and enhances their ability to help B cells

Agrewala, Javed N. ; Suvas, Susmit ; Joshi, Aneesh ; Bhatnagar, Archana ; Vinay, Dass S. ; Mishra, Gyan C. (2009) M150 modulates the costimulatory signals delivered by B cells to T cells and enhances their ability to help B cells Journal of Interferon and Cytokine Research, 18 (5). pp. 297-304. ISSN 1079-9907

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Official URL: http://www.liebertonline.com/doi/abs/10.1089/jir.1...

Related URL: http://dx.doi.org/10.1089/jir.1998.18.297

Abstract

There is a prerequirement of at least two sets of signals delivered by the antigen-presenting cell (APC) for the optimal activation of T helper (Th) cells. The First signal is provided by the engagement of T cell receptor with the antigen-MHC class II complex, followed by a second stimulus in the form of costimulatory signals. In the present study, we provide evidence that in a T-dependent antigen-driven system, the signals generated by hapten-specific B cells to stimulate Th cells for the secretion of interleukin-2 (IL-2), interferon-γ (IFN-γ ), and IL-4 were differentially modified by M150, a 150-kDa molecule expressed on the surface of macrophages. When ovalbumin-specific Th cells were cultured in the presence of 2,4,6 trinitrophenol (TNP)-specific B cells, M150 significantly increased the proliferation of Th cells and the secretion of IL-2 and IFN- γ and decreased the production of IL-4. Further, Th cells stimulated with M150 acquired improved ability to help B cells, resulting in an increase in the number of antibody-secreting cells and in the production of TNP-specific IgG2a antibodies. M150 possibly promotes Th1-like cell activity, as evidenced by predominant secretion of IL-2, IFN-γ , and IgG2a but not IL-4 and IgG1.

Item Type:Article
Source:Copyright of this article belongs to Mary Ann Liebert.
ID Code:68801
Deposited On:07 Nov 2011 04:57
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