Leishmania donovani infection of a susceptible host results in CD4+ T-Cell apoptosis and decreased Th1 cytokine production

Das, G. ; Vohra, H. ; Rao, K. ; Saha, B. ; Mishra, G. C. (1999) Leishmania donovani infection of a susceptible host results in CD4+ T-Cell apoptosis and decreased Th1 cytokine production Scandinavian Journal of Immunology, 49 (3). pp. 307-310. ISSN 0300-9475

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Official URL: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-...

Related URL: http://dx.doi.org/10.1046/j.1365-3083.1999.00486.x

Abstract

The disease visceral leishmaniasis is caused by a protozoan parasite, Leishmania donovani and is characterized by depressed cell-mediated immunity (CMI) and unhindered parasite growth in a susceptible host. The opposite trend is observed in a resistant host. However, the mechanism of this loss of CMI during the progressive disease is unknown as yet. In this report, we demonstrate that more than 40% of CD4+ T cells from a susceptible host undergo apoptosis resulting in a significant decrease in interleukin (IL)-2 and interferon (IFN)- secretion, leaving IL-4 secretion unaffected. These changes are not apparent in the case of CD4+ T cells derived from a resistant host. The data reported here suggest that experimental Leishmania donovani infection leads to selective deletion of the IL-2 and IFN-γ -secreting cells but not Th2-like cells in a susceptible but not a resistant host.

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