Tilak, Anup R. ; Kumar, Sachin ; Jain, Meenu ; Pant, Mohan C. ; Das, Bhudev C. ; Guleria, Randeep ; Mittal, Balraj ; Mathur, Neeraj ; Kumar, Ashwani (2011) Association of functionally important polymorphism of microsomal epoxide hydrolase gene (EPHX1) with lung cancer susceptibility Cancer Investigation, 29 (6). pp. 411-418. ISSN 0735-7907
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Official URL: http://informahealthcare.com/doi/abs/10.3109/07357...
Related URL: http://dx.doi.org/10.3109/07357907.2011.587070
Abstract
Distribution and gene-environment interaction of EPHX1 polymorphism was evaluated in 175 lung cancer patients and 322 controls from north India. Two novel non-synonymous, Lys117Arg and Leu263Phe, and twelve single nucleotide polymorphisms were identified in the present study. Binary logistic regression analysis showed association of polymorphism Tyr113His with increased risk of lung cancer (OR = 2.2, 95% CI = 1.2-4.0, p < .05). Gene-environment interaction revealed that patients with His113His and smoking habit had significantly greater risk of lung cancer (OR = 4.52, 95% CI = 0.93-43.05, p < .05). Present study provided evidence that EPHX1 polymorphism is associated with lung cancer susceptibility in Indian population.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa plc. |
| Keywords: | Lung Cancer; EPHX1; Single Nucleotide Polymorphism (SNP) |
| ID Code: | 68408 |
| Deposited On: | 07 Nov 2011 04:27 |
| Last Modified: | 07 Nov 2011 04:27 |
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