Kumar, Sachin ; Guleria, Randeep ; Mohan, Anant ; Singh, Vikas ; Bharti, Alok C. ; Das, Bhudev C. (2011) Efficacy of plasma TGF-β1 level in predicting therapeutic efficacy and prognosis in patients with advanced non-small cell lung cancer Cancer Investigation, 29 (3). pp. 202-207. ISSN 0735-7907
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Official URL: http://informahealthcare.com/doi/abs/10.3109/07357...
Related URL: http://dx.doi.org/10.3109/07357907.2010.543208
Abstract
We hypothesized that serial assessment of TGF-β1 during chemotherapy might predict therapeutic response and prognosis in non-small cell lung cancer (NSCLC) patients. Plasma TGF-β1 levels were quantified before first, second, and third cycles of chemotherapy in 42 advanced NSCLC patients and correlated with therapeutic response. Plasma TGF-β1 levels measured before first and second cycles of chemotherapy failed to predict response to therapy. The increased presence of TGF-β1 measured before second and third cycles of chemotherapy was associated with poor survival. Estimation of plasma TGF-β1 during the course of chemotherapy might not be a reliable biomarker for predicting therapeutic efficacy in NSCLC.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa plc. |
| Keywords: | Cancer Biomarkers; Chemotherapy; Lung Cancer; Prognosis; Response Predictions |
| ID Code: | 68402 |
| Deposited On: | 07 Nov 2011 04:26 |
| Last Modified: | 07 Nov 2011 04:26 |
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