Interaction of antimalarial drugs with Hemin

Panijpan, B. ; Mohan Rao, Ch. ; Balasubramanian, D. (1983) Interaction of antimalarial drugs with Hemin Bioscience Reports, 3 (12). pp. 1113-1117. ISSN 0144-8463

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Hemin (ferriprotoporphyrin IX) is shown to form complexes with the chloroquine class of antimalarial drugs. The Soret band of hemin becomes optically active upon the addition of chiral drugs. Results on the hemin-induced quenching of the fluorescence of chloroquine are consistent with the formation of a 21 hemin:drug complex with a formation constant of 1.4× 107 at 298 K. Also a direct comparison of the drug-treated and drug-free parasites themselves, by the noninvasive photoacoustic spectroscopic method, reveals an in vivo interaction between endogenous hemin and the added drug.

Item Type:Article
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ID Code:67997
Deposited On:02 Nov 2011 03:02
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