Dengue virus-specific suppressor T cells: current perspectives

Chaturvedi, Umesh C. ; Shrivastava, Richa ; Tripathi, Raj K. ; Nagar, Rachna (2007) Dengue virus-specific suppressor T cells: current perspectives FEMS Immunology & Medical Microbiology, 50 (3). pp. 285-299. ISSN 0928-8244

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Dengue virus was the first microorganism that was shown to induce generation of antigen-specific suppressor T (TS) cells in mice. The cascade of the three generations of TS cells (TS1, TS2, TS3) and their secretary products, the suppressor factors (SF1, SF2), was delineated. The TS pathway was proposed to be protective through inhibition of the production of enhancing antibody, which may enhance the severity of dengue disease. The currently second most favoured mechanism of severe dengue disease is the 'cytokine tsunami'. During the last decade, suppressor/regulatory T cells have been studied in greater detail using modern techniques in various diseases, including viral infections. This brief review discusses the role of dengue-specific suppressor T cells in protection and/or induction of severe dengue disease in view of our current understanding of suppressor/regulatory T cells.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Microbiological Societies.
Keywords:Dengue Virus; DHF; Suppressor T Cell; Regulatory T Cell; Pathogenesis
ID Code:6788
Deposited On:26 Oct 2010 06:01
Last Modified:16 May 2016 17:05

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