Evidence for latency of Japanese encephalitis virus in T lymphocytes

Mathur, Asha ; Kulshreshtha, R. ; Chaturvedi, U. C. (1989) Evidence for latency of Japanese encephalitis virus in T lymphocytes Journal of General Virology, 70 . pp. 461-465. ISSN 0022-1317

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Official URL: http://vir.sgmjournals.org/cgi/content/abstract/70...

Related URL: http://dx.doi.org/10.1099/0022-1317-70-2-461


Activation of latent Japanese encephalitis virus (JEV) in the spleen has been studied by co-cultivation with allogeneic or syngeneic cells. Activated virus was isolated by cocultivation from T lymphocytes of spleen, as shown by indirect immunofluorescence or by inoculation into mice. The B lymphocytes and macrophages of latently infected mice did not reactivate the virus. A higher proportion of Lyt 1 cells than Lyt 2 cells were harbouring JEV as shown by indirect immunofluorescence. The spleen cells from latently infected mice elicited the lymphoproliferative response but this was much lower than that observed in the controls. These findings suggest the establishment of latent JEV infection in T lymphocytes.

Item Type:Article
Source:Copyright of this article belongs to Society for General Microbiology.
Keywords:JEV; T Lymphocytes; Latency
ID Code:6783
Deposited On:22 Oct 2010 06:46
Last Modified:16 May 2016 17:05

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