Cytotoxicity of filtrates of haemolytic Escherichia coli

Chaturvedi, U. C. ; Mathur, Asha ; Khan, A. M. ; Mehrotra, R. M. L. (1969) Cytotoxicity of filtrates of haemolytic Escherichia coli Journal of Medical Microbiology, 2 . pp. 211-218. ISSN 0022-2615

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Official URL: http://jmm.sgmjournals.org/cgi/content/abstract/2/...

Related URL: http://dx.doi.org/10.1099/00222615-2-3-211

Abstract

The diffusible haemolysin of Escherichia coli is highly cytotoxic to chick embryo cell cultures, but has no effect on monkey kidney and mouse embryo cell cultures. The cytotoxic effects are specific, as they can be neutralised by specific antisera. Culture fluids from non-haemolytic strains of E. coli are non-cytotoxic. The haemolytic activity is thermolabile, but cytotoxicity is thermostable. The antibodies prepared against heated or unheated haemolysins prevent cytotoxicity, but haemolytic activity is neutralised only by antisera prepared against unheated haemolysin. Fraction A of haemolysin is non-haemolytic and non-cytotoxic, whereas fraction B is non-haemolytic but is cytotoxic. The haemolytic and cytotoxic factors of Escherichia coli appear, therefore, not to be identical.

Item Type:Article
Source:Copyright of this article belongs to Society for General Microbiology.
ID Code:6746
Deposited On:22 Oct 2010 06:26
Last Modified:16 May 2016 17:03

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