Effect of nanocavity confinement on the rotational relaxation dynamics: 3-acetyl-4-oxo-6,7-dihydro-12H indolo-[2,3-a] quinolizine in micelles

Das, Paramita ; Mallick, Arabinda ; Chakrabarty, Alok ; Haldar, Basudeb ; Chattopadhyay, Nitin (2006) Effect of nanocavity confinement on the rotational relaxation dynamics: 3-acetyl-4-oxo-6,7-dihydro-12H indolo-[2,3-a] quinolizine in micelles Journal of Chemical Physics, The, 125 (4). 044516-044521. ISSN 0021-9606

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Official URL: http://link.aip.org/link/?JCPSA6/125/044516/1

Related URL: http://dx.doi.org/10.1063/1.2219751

Abstract

In continuation of our recent study on the steady state photophysics of a biologically active β-carboline derivative, 3-acetyl-4-oxo-6,7-dihydro-12H indolo-[2,3-a] quinolizine (AODIQ), in the present article we have investigated the effect of nanocavity confinement on the excited state dynamics and rotational relaxation of the probe using picosecond time resolved fluorescence and fluorescence anisotropy techniques. The polarity dependent intramolecular charge transfer process is responsible for the remarkable sensitivity of this biological fluorophore in micellar environments. The fluorescence anisotropy decay of AODIQ incorporated inside the micelle is biexponential. The rotational motion of the probe was interpreted on the basis of a two step model consisting of a fast restricted rotation of the probe and a slow lateral diffusion of the probe in the micelle; both coupled to the overall rotation of the micelle. Experimental results reveal that micellar environment causes significant retardation of both the wobbling as well as the translational motion of the probe.

Item Type:Article
Source:Copyright of this article belongs to American Institute of Physics.
Keywords:Organic Compounds; Molecular Biophysics; Fluorescence; Time Resolved Spectra; Charge Exchange; Biodiffusion; Excited States; Rotational States
ID Code:67432
Deposited On:31 Oct 2011 04:55
Last Modified:31 Oct 2011 04:55

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