Role of interleukin-12 in patients with dengue hemorrhagic fever

Pacsa, A. S. ; Agarwal, R. ; Elbishbishi, E. A. ; Chaturvedi, U. C. ; Nagar, R. ; Mustafa, A. S. (2000) Role of interleukin-12 in patients with dengue hemorrhagic fever FEMS Immunology & Medical Microbiology, 28 (2). pp. 151-155. ISSN 0928-8244

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Interleukin (IL)-12 has a broad range of activities including regulation of cytokine synthesis and selective promotion of Th1-type cell development. A shift from a Th1-type response to Th2-type has been suggested to be important in the pathogenesis of dengue hemorrhagic fever (DHF). This study was undertaken to investigate the possible role of IL-12 in this shift. A total of 76 patients with various grades of dengue illness and 21 normal healthy controls were tested for IL-12 levels in serum samples and IL-12 mRNA in their peripheral blood mononuclear cells. The results showed that the levels of IL-12 were the highest in patients with dengue fever (270± 102 pg ml-1) followed by decreasing levels in the patients with DHF grade I (198± 86 pg ml-1; P<0.05) and DHF grade II (84± 52 pg ml-1; P<0.001). Neither IL-12 nor its mRNA could be detected in the patients with DHF grades III and IV. The cytokine appeared and reached peak levels during the first 4 days of illness, started to decline by day 5-8 and disappeared by day 9 onwards. The absence of IL-12 during severe illness and late phases of the disease may be responsible for the shift to a Th2-type response and thus for the pathogenesis of DHF.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Microbiological Societies.
Keywords:Dengue; Dengue Hemorrhagic Fever; IL-12; Cytokine; Pathogenesis
ID Code:6717
Deposited On:22 Oct 2010 06:14
Last Modified:16 May 2016 17:01

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