Serological evidence of human klassevirus infection

Greninger, Alexander L. ; Holtz, Lori ; Kang, Gagandeep ; Ganem, Donald ; Wang, David ; DeRisi, Joseph L. (2010) Serological evidence of human klassevirus infection Clinical and Vaccine Immunology, 17 (10). pp. 1584-1588. ISSN 1556-6811

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Klassevirus is a proposed new genus of picornavirus that has been associated with pediatric diarrhea. In this study, we used recombinant klassevirus 3C protease as the capture antigen for an indirect serological enzyme-linked immunosorbent assay (ELISA). Four of six klassevirus reverse transcription (RT)-PCR-positive individuals demonstrated seroconversion against the 3C protease, suggesting that klassevirus infection and replication occur in humans. Additional screening of 353 samples from an age-banded serological cohort from two St. Louis hospitals indicated a seroprevalence of 6.8%.

Item Type:Article
Source:Copyright of this article belongs to American Society for Microbiology.
ID Code:67091
Deposited On:28 Oct 2011 11:22
Last Modified:28 Oct 2011 11:22

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