Sowmyanarayanan, Thuppal Varadachari ; Natarajan, Sathish Kumar ; Ramachandran, Anup ; Sarkar, Rajiv ; Moses, Prabhakar Devarajan ; Simon, Anna ; Agarwal, Indira ; Christopher, Solomon ; Kang, Gagandeep (2009) Nitric oxide production in acute gastroenteritis in Indian children Transactions of the Royal Society of Tropical Medicine & Hygiene, 103 (8). pp. 849-851. ISSN 0035-9203
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.trstmh.2009.05.003
Abstract
This study compared nitric oxide (NO) levels in 110 children with, and 110 children without, infectious gastroenteritis. Post-infection intestinal function was assessed in a subset. At least one pathogen was identified in 47.2% of cases. The most common diarrhoeal pathogens were rotavirus (22.7%) and norovirus genogroup II (11.8%). The levels of NO measured by median urinary nitrite:creatinine ratio were significantly higher in children with diarrhoea [23.6; interquartile range (IQR) 12.3-46.7] than without diarrhoea (7.8; IQR 4.1-13.2), P < 0.001. The ratio was not significantly different between diarrhoeal cases with and without pathogens (P = 0.148). Six of twelve children tested had intestinal dysfunction.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Acute Gastroenteritis; Nitric Oxide; Rotavirus; Intestinal Permeability; Children; India |
| ID Code: | 67001 |
| Deposited On: | 28 Oct 2011 11:21 |
| Last Modified: | 28 Oct 2011 11:21 |
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