Torres-Larios, Alfredo ; Dock-Bregeon, Anne-Catherine ; Romby, Pascale ; Rees, Bernard ; Sankaranarayanan, Rajan ; Caillet, Joel ; Springer, Mathias ; Ehresmann, Chantal ; Ehresmann, Bernard ; Moras, Dino (2002) Structural basis of translational control by Escherichia coli threonyl tRNA synthetase Nature Structural Biology, 9 . pp. 343-347. ISSN 1072-8368
Full text not available from this repository.
Official URL: http://www.nature.com/nsmb/journal/v9/n5/abs/nsb78...
Related URL: http://dx.doi.org/10.1038/nsb789
Abstract
Escherichia coli threonyl-tRNA synthetase (ThrRS) represses the translation of its own messenger RNA by binding to an operator located upstream of the initiation codon. The crystal structure of the complex between the core of ThrRS and the essential domain of the operator shows that the mRNA uses the recognition mode of the tRNA anticodon loop to initiate binding. The final positioning of the operator, upon which the control mechanism is based, relies on a characteristic RNA motif adapted to the enzyme surface. The finding of other thrS operators that have this conserved motif leads to a generalization of this regulatory mechanism to a subset of Gram-negative bacteria.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to Nature Publishing Group. |
ID Code: | 66874 |
Deposited On: | 28 Oct 2011 04:01 |
Last Modified: | 28 Oct 2011 04:01 |
Repository Staff Only: item control page