Dengue in infants: an overview

Jain, Amita ; Chaturvedi, Umesh C. (2010) Dengue in infants: an overview FEMS Immunology & Medical Microbiology, 59 (2). pp. 119-130. ISSN 0928-8244

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Dengue virus (DV) infection causes either a benign syndrome, dengue fever, or a severe syndrome, dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS), that is characterized by systemic capillary leakage, thrombocytopaenia and hypovolaemic shock. DHF/DSS occur mainly due to secondary infection by a heterotype DV infection in children and adults but in infants even primary infection by DV causes DHF/DSS. Clinical manifestations of DHF/DSS are more significantly associated with death in infants compared with older children. Vertical transmission of DV and anti-DV IgG has been well reported and is responsible for the pathogenesis of DV disease and its manifestations in infants. The complex pathogenesis of DHF/DSS during primary dengue in infants, with multiple age-related confounding factors, offers unique challenges to investigators. Dengue in infants is not often studied in detail due to practical limitations, but looking at the magnitude of DHF/DSS in infants and the unique opportunities this model provides, there is a need to focus on this problem. This paper reviews existing knowledge on this aspect of DV infection and the challenges it provides.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Microbiological Societies.
Keywords:Dengue Virus; Dengue Haemorrhagic Fever; Pathogenesis; Antibody-dependent Enhancement; Cytokine Tsunami; Regulatory T Cell
ID Code:6680
Deposited On:22 Oct 2010 05:31
Last Modified:28 May 2011 06:52

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