Sazawal, Sudha ; Hasan, Syed Khizer ; Dutta, Pankhi ; Kumar, Bijender ; Kumar, Rajat ; Kumar, Lalit ; Choudhry, V. P. ; Saxena, Renu (2005) Over-representation of bcr3 subtype of PML/RAR α fusion gene in APL in Indian patients Annals of Hematology, 84 (12). pp. 781-784. ISSN 0939-5555
Full text not available from this repository.
Official URL: http://www.springerlink.com/content/g640w575165410...
Related URL: http://dx.doi.org/10.1007/s00277-005-1095-4
Abstract
Thirty six patients with acute promyelocytic leukemia were studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time PCR. There was concordance between the results achieved by both the methods except in one case, which was negative by RT-PCR but positive by real-time PCR. The prevalence of bcr3 (short isoform) was found to be significantly higher than that of bcr1 (long isoform ) (64 vs. 36%, P=0.03). No correlation was found between age, sex, and white blood cell (WBC) count at diagnosis. Molecular remission was achieved in 66.6% of patients with bcr3 isoform. Median WBC count at presentation was found to be higher than that in the West.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer. |
| Keywords: | Acute Promyelocytic Leukemia; PML; RARα Isoform; Hematological Remission; Molecular Remission; Reverse Transcription-polymerase Chain Reaction (RT-PCR); Real-time PCR |
| ID Code: | 66768 |
| Deposited On: | 27 Oct 2011 06:32 |
| Last Modified: | 27 Oct 2011 06:32 |
Repository Staff Only: item control page
