Absence of human papillomavirus DNA in breast cancer as revealed by polymerase chain reaction

Gopalkrishna, V. ; Singh, U. R. ; Sodhani, P. ; Sharma, J. K. ; Hedau, S. T. ; Mandal, A. K. ; Das, B. C. (1996) Absence of human papillomavirus DNA in breast cancer as revealed by polymerase chain reaction Breast Cancer Research and Treatment, 39 (2). pp. 197-202. ISSN 0167-6806

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Official URL: http://www.springerlink.com/index/Q117552283M1220X...

Related URL: http://dx.doi.org/10.1007/BF01806186

Abstract

Oncogenic human papillomavirus (HPV) types 16 and 18 commonly associated with cervical cancer are found in many epithelial malignancies at extra-genital sites including breast. The transforming gene products of HPV have also been shown to immortalize breast epithelial cellsin vitro. But the findings of HPV DNA in breast carcinoma are found to be contradictory. In the present study fine needle aspirate cell (FNAC) samples from 26 breast cancer patients and four breast tumour biopsies were analysed for the presence of HPV 16 and 18 DNA sequences by both polymerase chain reaction (PCR) and Southern blot hybridization. Of 26 fine needle aspi rate cell samples and four breast cancer biopsies, not a single sample was found to be positive by either PCR or Southern blot hybridization. The observation of complete absence of HPV DNA sequences in breast cancer refute the possibility of any role for oncogenic genital HPV types 16 and 18 in the pathogenesis of breast cancer.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Breast Cancer; Fine Needle Aspirate Cell; Human Papillomavirus; PCR; Southern Blot Hybridization
ID Code:66695
Deposited On:27 Oct 2011 04:20
Last Modified:27 Oct 2011 04:20

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