Conformational studies on cyclic dipeptides

Ramani, R. ; Sasisekharan, V. ; Venkatesan, K. (1977) Conformational studies on cyclic dipeptides Chemical Biology & Drug Design, 9 (4). pp. 277-292. ISSN 1747-0277

Full text not available from this repository.

Official URL:

Related URL:


An analysis of 11 crystal structures of cyclic dipeptides so far reported in the literature is made, with main reference to the internal parameters of these molecules. Preferred conformations of the side chains of cyclic dipeptides with different α-amino acid residues have been studied by classical energy calculations. The possible conformations of the DKP ring are also studied. The significance of the non-bonded interaction in deciding the pathway for conformational change has also been investigated. The agreement between theoretical results and experimental observations is quite good, both with respect to the conformation of these molecules as well as the enthalpy difference as estimated from n.m.r. studies between different conformers.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
ID Code:66670
Deposited On:27 Oct 2011 04:03
Last Modified:13 Jul 2012 08:43

Repository Staff Only: item control page