Effect of phospholipid enrichment on nystatin action: differences in antibiotic sensitivity between in vivo and in vitro conditions

Rao, T. V. ; Das, S. ; Prasad, R. (1985) Effect of phospholipid enrichment on nystatin action: differences in antibiotic sensitivity between in vivo and in vitro conditions Microbios, 42 (169-170). pp. 145-153. ISSN 0026-2633

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Abstract

Polyene-nystatin had a selective effect on the transport of glutamic acid and lysine in phosphatidylcholine-, or phosphatidylethanolamine-enriched cells of Saccharomyces cerevisiae. However, liposomes prepared from lipid extracts from the same cells did not mimic the results of in vivo studies. Our in vitro results demonstrated that factors other than sterols, e.g. phospholipid enrichment, protein lipid interactions and lipid bilayer asymmetry may also affect the overall susceptibility of polyene antibiotics.

Item Type:Article
Source:Copyright of this article belongs to Faculty Press, Cambridge.
ID Code:66271
Deposited On:24 Oct 2011 08:30
Last Modified:24 Oct 2011 08:30

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