Gour, Nidhi ; Purohit, Chandra Shekhar ; Verma, Sandeep ; Puri, Rajat ; Ganesh, Subramaniam (2009) Mannosylated self-assembled structures for molecular confinement and gene delivery applications Biochemical and Biophysical Research Communications, 378 (3). pp. 503-506. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bbrc.2008.11.070
Abstract
This paper reports self-assembly of a lysine conjugated with a biantennary mannose to form spherical structures. These supramolecular structures are found to be hollow in nature and they afford effective encapsulation of alkaline phosphatase enzyme, plasmid DNA and a GFP reporter gene, which was transfected in COS-7 cells. Loaded hollow structures also get disrupted upon mild sonication, releasing encapsulated molecules thereby illustrating their potential for confinement and delivery applications.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Self-assembly; Nanocontainers; Hollow Spheres; Nanoreactor; Cell Transfection; COS-7 Cells |
| ID Code: | 66253 |
| Deposited On: | 21 Oct 2011 10:02 |
| Last Modified: | 21 Oct 2011 10:02 |
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