Gupta, Yogita ; Mathur, G. N. ; Parvez, Masood ; Verma, Sandeep (2006) Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants Bioorganic & Medicinal Chemistry Letters, 16 (20). pp. 5364-5367. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2006.07.077
Abstract
This report describes a novel carboxyl pendant containing adenylated polymeric template, its metalation with Zn (II), and manifestation of catalytic activity for the hydrolysis of model phosphodiester, bis(p-nitrophenyl) phosphate (bNPP), and plasmid cleavage. Observation of a bell-shaped pH-Kobs profile suggested influence of pH variation over hydrolysis rate. This metalated polymer also afforded facile relaxation of pBR322 supercoiled DNA, with an interesting reusability feature intricately associated with heterogeneous catalysis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Plasmid Cleavage; Catalysis; Adenine; Polymer; Zinc |
| ID Code: | 66240 |
| Deposited On: | 21 Oct 2011 09:45 |
| Last Modified: | 21 Oct 2011 09:45 |
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