Catalytic transformations with copper-metalated diglycine conjugates

Madhavaiah, C. ; Parvez, Masood ; Verma, Sandeep (2004) Catalytic transformations with copper-metalated diglycine conjugates Bioorganic & Medicinal Chemistry, 12 (22). pp. 5973-5982. ISSN 0968-0896

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A series of copper-metalated, water-soluble bis-diglycine conjugates were synthesized and characterized through spectroscopic methods. These conjugates were evaluated for the cleavage of phosphodiester substrates, supercoiled plasmid relaxation in the presence of co-oxidants, and for the oxidation of a diphenolic substrate, 2,6-dimethoxyphenol. Appreciable rate enhancements were observed for these reactions and the oxidative nucleolytic cleavage activity and phenol oxidative coupling was presumably manifested via formation of reactive oxygen species.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Diglycine; Copper; Catalysis; Plasmid; Oxidation
ID Code:66221
Deposited On:21 Oct 2011 09:44
Last Modified:21 Oct 2011 09:44

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