Silver-catalyzed intramolecular cyclization of 9-propargyladeninevia N3 alkylation

Prajapati, Rajneesh Kumar ; Kumar, Jitendra ; Verma, Sandeep (2010) Silver-catalyzed intramolecular cyclization of 9-propargyladeninevia N3 alkylation Chemical Communications, 46 (19). pp. 3312-3314. ISSN 1359-7345

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2010...

Related URL: http://dx.doi.org/10.1039/C001947J

Abstract

We report the formation of a highly unusual fused, tricyclic purine derivative via N3 alkylation of 9-propargyladenine, upon activation of the acetylenic triple bond by Ag(I) ions. The participation of silver ions in this process might offer newer design paradigms for minor groove N3 DNA alkylation, antibacterial and anticancer agents.

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