Madhavaiah, C. ; Verma, Sandeep (2005) Copper-metalated peptide palindrome derived from prion octarepeat: synthesis, aggregation, and oxidative transformations Bioorganic & Medicinal Chemistry, 13 (9). pp. 3241-3248. ISSN 0968-0896
Full text not available from this repository.
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmc.2005.02.029
Abstract
We report construction of a bis-pentapeptide conjugate 4 containing truncated pentapeptide sequence from prion octarepeats. Its copper-laden derivative 5 demonstrated a propensity for aggregate formation, which was studied by atomic force microscopy. Oxidative biochemical transformations catalyzed by 5 were evaluated by nucleic acid cleavage and by neurotransmitter oxidation, in the presence of external co-oxidants. Preliminary mechanistic analysis provides a hint for the involvement of reactive oxygen species in such transformations.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Prion; Copper; Conjugate; Aggregation |
| ID Code: | 66193 |
| Deposited On: | 21 Oct 2011 09:45 |
| Last Modified: | 21 Oct 2011 09:45 |
Repository Staff Only: item control page
