Phased fiber growth in a peptide conjugate: aggregation and disaggregation studies

Ghosh, Surajit ; Verma, Sandeep (2007) Phased fiber growth in a peptide conjugate: aggregation and disaggregation studies The Journal of Physical Chemistry B, 111 (14). pp. 3750-3757. ISSN 1089-5647

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Official URL: http://pubs.acs.org/doi/abs/10.1021/jp066546a

Related URL: http://dx.doi.org/10.1021/jp066546a

Abstract

A glycine-rich, short pentapeptide conjugate 6, derived from the highly conserved copper-binding octarepeat region of the prion protein, exhibits a tendency to self-aggregate in a time-dependent fashion. Aging of 6 afforded an insight into the phased growth of spherical prefibrillar structures to fibers of long persistence length, as observed by a combination of microscopic techniques. Interestingly, growth of these fibers was inhibited by colchicine, a known inhibitor of microtubule polymerization in a concentration dependent fashion. This study offers an intriguing insight into the occurrence of prefibrillar intermediates on the path to the formation of full length peptide fibers. It is also envisaged that constructs such as 6 may also serve as simple models to study chemical intervention of protein aggregation.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:66182
Deposited On:21 Oct 2011 09:59
Last Modified:21 Oct 2011 09:59

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