Ranganathan, Subramania ; Jayaraman, Narayanaswamy ; Roy, Raja ; Madhusudanan, K. P. (1993) A short serendipitous synthesis of minimal glucocorticoid receptor zinc template Tetrahedron Letters, 34 (48). pp. 7801-7804. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0040-4039(00)61571-X
Abstract
The serendipitous formation of the novel, 20 membered, cyclo[bis-oxalyl cystine] - on treatment of cystine-di-OMe with oxalyl chloride - has provided an exceptionally short route to the first synthesis of the glucocorticoid receptor zinc template via PDT mediated thiol-disulfide exchange and metal complexation. The fortuitous formation of the novel cyclo[bis- oxalyl cystine] (1) from cystine-di-OMe has enabled a one-step synthesis of the first minimal glucocorticoid receptor zinc template(2).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 65986 |
| Deposited On: | 20 Oct 2011 07:08 |
| Last Modified: | 15 Jul 2012 10:07 |
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