Highly efficient propane-1,3-dithiol mediated thiol-disulphide interchange: a facile and clean methodology for S-S reduction in peptides

Ranganathan, Subramania ; Jayaraman, Narayanaswamy (1991) Highly efficient propane-1,3-dithiol mediated thiol-disulphide interchange: a facile and clean methodology for S-S reduction in peptides Journal of the Chemical Society, Chemical Communications (14). pp. 934-936. ISSN 0022-4936

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/1991...

Related URL: http://dx.doi.org/10.1039/C39910000934

Abstract

Propane-1,3-dithiol, at room temperature and in the absence of any promoter, neatly brings about the S-S → 2SH change, and the latter can be isolated as acrylonitrile adducts; the methodology has been tested with several substrates including c-lysozyme, insulin and oxytocin, and spontaneous imidazole promoted S-deprotection was observed in the case of Z-Cys(S-CH2CH2CN)His-OMe.

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