Functional MRI shows activation of the medial preoptic area during sleep

Khubchandani, M. ; Jagannathan, N. R. ; Mallick, H. N. ; Kumar, Velayudhan Mohan (2005) Functional MRI shows activation of the medial preoptic area during sleep NeuroImage, 26 (1). pp. 29-35. ISSN 1053-8119

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Changes in the activity of the basal forebrain sleep regulating areas were studied noninvasively in conscious rats by employing functional magnetic resonance imaging (fMRI). Sleep-wakefulness (S-W) stages were identified with the help of electrophysiological recordings carried out simultaneously. An increase in the signal intensity was observed in the medial preoptic area (mPOA) during sleep indicating a heightened activity of neurons in this area. In some rats, there was a decrease in the activity of the fronto-parietal cortex. The sleep-induced increase in activity in the mPOA and decrease in the fronto-parietal cortex are in relation to their levels in the awake state. The findings helped to localize the critical area for the maintenance of slow wave sleep at the mPOA. These results further corroborate some of the previous suggestions based on neurotoxic lesion, chemical stimulation and electrophysiological recordings.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Sleep; Medial Preoptic Area; fMRI; Electrophysiology; Conscious Rat; Activation; Fronto-parietal Cortex
ID Code:65874
Deposited On:19 Oct 2011 14:31
Last Modified:19 Oct 2011 14:31

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