Regulation of N-acetylglucosamine kinase synthesis in yeast

Bhattacharya, A. ; Banerjee, S. ; Datta, A. (1974) Regulation of N-acetylglucosamine kinase synthesis in yeast Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 374 (3). pp. 384-391. ISSN 0005-2787

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The presence of N-acetylglucosamine source is essential for the induced synthesis of N-acetylglucosamine kinase (ATP : 2-acetylamino-2-deoxy-D-glucose-6-phosphotransferase) in a wildtype strain of Candida albicans. The enzyme synthesis stops and its concentration in the cells declines rapidly as soon as 2-acetylamino-2-deoxy-D-glucose (GlcNAc) is removed from the medium. Cycloheximide, an inhibitor of protein synthesis completely prevents induction of N-acetylglucosamine kinase. Further, by blocking the RNA synthesis by actinomycin D or by suppressing the transport of nuclear mRNA to cytoplasm by cordycepin (3'-deoxyadenosine), no further synthesis of the kinase is observed. However, inhibition of DNA synthesis either by hydroxyurea or by mitomycin-C does not impair the synthesis of N-acetylglucosamine kinase.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:65817
Deposited On:19 Oct 2011 08:49
Last Modified:19 Oct 2011 08:49

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