Application of the Suzuki-Miyaura cross-coupling reaction for the modification of phenylalanine peptides

Kotha, Sambasivarao ; Lahiri, Kakali (2003) Application of the Suzuki-Miyaura cross-coupling reaction for the modification of phenylalanine peptides Biopolymers, 69 (4). pp. 517-528. ISSN 0006-3525

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/bip.104...

Related URL: http://dx.doi.org/10.1002/bip.10420

Abstract

We have demonstrated an exceptionally simple and a useful methodology for modification of unusual phenylalanine peptides by adapting the building block approach using the Suzuki-Miyaura cross-coupling reaction as a key step. This strategy gave a good overall yield of various modified tri- and pentapeptides that may be useful to prepare various biologically active peptides in a short period of time.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Suzuki-Miyaura Coupling; Post-translational Peptide Modifications; Boronic Acids; Heterocycles; Combinatorial Chemistry
ID Code:65198
Deposited On:15 Oct 2011 11:40
Last Modified:15 Oct 2011 11:40

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