Modification of constrained peptides by ring-closing metathesis reaction

Kotha, Sambasivarao ; Sreenivasachary, Nampally ; Mohanraja, Kumar ; Durani, Susheel (2001) Modification of constrained peptides by ring-closing metathesis reaction Bioorganic & Medicinal Chemistry Letters, 11 (11). pp. 1421-1423. ISSN 0960-894X

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/S0960-894X(01)00227-X

Abstract

Ring-closing metathesis (RCM) with α,α-diallylglycyl peptides is shown to furnish α,α-cyclopentenylglycyl peptides as conformationally restrained analogues in the form of post-translational type peptide modification suitable for both peptidomimetic and combinatorial chemistry applications.

Item Type:Article
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ID Code:65167
Deposited On:15 Oct 2011 11:38
Last Modified:15 Oct 2011 11:38

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