Kotha, Sambasivarao ; Singh, Kuldeep (2004) N-Alkylation of diethyl acetamidomalonate: synthesis of constrained amino acid derivatives by ring-closing metathesis Tetrahedron Letters, 45 (52). pp. 9607-9610. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2004.11.013
Abstract
An efficient method for N-alkylation of diethyl acetamidomalonate (DEAM) is reported. C-Alkenylation was achieved by treating the N-alkenylated DEAM with various electrophiles in the presence of Cs2CO3. RCM reactions of C- and N-alkenylated products gave cyclic amino acid derivatives in good yields.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Diethyl Acetamidomalonate; Regioselective N-alkylation; Metathesis; Constrained Amino Acid Derivatives; Heterocycles |
| ID Code: | 65166 |
| Deposited On: | 15 Oct 2011 11:42 |
| Last Modified: | 15 Oct 2011 11:42 |
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