Critical cation balance in B → Z transition: role of Li+

Ramesh, N. ; Brahmachari, Samir K. (1983) Critical cation balance in B → Z transition: role of Li+ FEBS Letters, 164 (1). pp. 33-37. ISSN 0014-5793

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Official URL: http://dx.doi.org//10.1016/0014-5793(83)80013-1

Related URL: http://dx.doi.org/10.1016/0014-5793(83)80013-1

Abstract

The sodium salt of poly(dG---dC) is known to exhibit a B → Z transition in the presence of various cations and 60% alcohol. We here show that the lithium salt of poly(dG---dC) does not undergo B → Z transition in the presence of 60% alcohol since Li+ with its large hydration shell cannot stabilize the Z-form. On the other hand, high concentrations of Mg2+ or micromolar concentrations of the cobalt hexamine complex which are known to stabilize the Z-form can compete with Li+ for charge neutralization and hence bring about a B → Z transition in the same polymer. From the model building studies the mode of action of the cobalt-hexamine complex in stabilizing the Z-form is postulated.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Biochemical Societies.
Keywords:B → Z transition; Circular dichroism; Poly(dG---dC) Li salt; Cobalt-hexamine binding
ID Code:6454
Deposited On:20 Oct 2010 10:21
Last Modified:16 May 2016 16:47

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