Effect of Cytokine-encoding plasmid delivery on immune response to Japanese encephalitis virus DNA vaccine in mice

Bharati, Kaushik ; Appaiahgari Mohan, Babu ; Vrati, Sudhanshu (2005) Effect of Cytokine-encoding plasmid delivery on immune response to Japanese encephalitis virus DNA vaccine in mice Microbiology and Immunology, 49 (4). pp. 349-353. ISSN 0385-5600

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Official URL: http://sciencelinks.jp/j-east/article/200509/00002...

Abstract

We have previously shown that immunization of mice with plasmid pMEa synthesizing Japanese encephalitis virus (JEV) envelope protein induced anti-JEV humoral and cellular immune responses. We now show that intra-muscular co-administration of mice with pMEa and pGM-CSF, encoding murine granulocyte-macrophage colony-stimulating factor or pIL-2, encoding murine interleukin-2 given 4 days after pMEa, augmented anti-JEV antibody titers. This did not enhance the level of protection in immunized mice against JEV. However, intra-dermal co-administration of pMEa and pGM-CSF in mice using the gene gun, enhanced anti-JEV antibody titers resulting in an increased level of protection in mice against lethal JEV challenge.

Item Type:Article
Source:Copyright of this article belongs to Center for Academic Publications, Japan.
ID Code:64006
Deposited On:22 Nov 2011 08:52
Last Modified:22 Nov 2011 08:52

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