Synthesis and mycobacterial growth inhibition activities of bivalent and monovalent arabinofuranoside containing alkyl glycosides

Naresh, Kottari ; Bharati, Binod Kumar ; Jayaraman, Narayanaswamy ; Chatterji, Dipankar (2008) Synthesis and mycobacterial growth inhibition activities of bivalent and monovalent arabinofuranoside containing alkyl glycosides Organic & Biomolecular Chemistry, 6 (13). pp. 2388-2393. ISSN 1477-0520

Full text not available from this repository.

Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2008...

Related URL: http://dx.doi.org/10.1039/B803409E

Abstract

Arabinofuranosides constitute one of the important components of cell wall structures of mycobacteria. With this importance of arabinofuranosides in mind, alkyl glycosides bearing arabinofuranoside trisaccharides were prepared, wherein the sugars were presented either in the monovalent or bivalent forms. Following the synthesis, the monovalent and bivalent alkyl glycosides were tested for their activities in a mycobacterial growth assay. The growth of the mycobacterial strain M. smegmatis was assessed in the presence of the alkyl glycosides and it was realized that the alkyl glycosides acted as inhibitors of the mycobacterial growth. The inhibition of the growth, caused by the above alkyl glycosides, was not observed for the arabinofuranose trisaccharide alone, without the alkyl groups, and for an alkyl glycoside bearing maltose as the sugar component.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:6392
Deposited On:20 Oct 2010 10:31
Last Modified:15 Jul 2012 10:09

Repository Staff Only: item control page