Effect of REM sleep deprivation on rat brain acetylcholinesterase

Thakkar, Mahesh ; Mallick, Birendra Nath (1991) Effect of REM sleep deprivation on rat brain acetylcholinesterase Pharmacology Biochemistry and Behavior, 39 (1). pp. 211-214. ISSN 0091-3057

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Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0091-3057(91)90424-Z


Acetylcholinesterase activity was compared in control, rapid eye movement sleep-deprived and recovered rat brain. The activity was estimated in the whole brain, cerebrum, brain stem and cerebellum. Flower pot technique was used for continuing deprivation for two, four and eight days. The results showed that the enzyme activity increased signficantly in the deprived rat brain and it returned to control/normal level on recovery. The enzyme activity increased first in the brain stem, while the activity in the cerebellum showed no significant change. Control experiments suggest that the increase was primarily caused by the deprivation. The finding fits well with existing knowledge and would possibly help in explaining earlier observations.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Acetylcholinesterase; Rapid Eye Movement Sleep; Deprivation; Platform
ID Code:63678
Deposited On:29 Sep 2011 06:17
Last Modified:29 Sep 2011 06:17

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