Enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-Nebivolol

Chandrasekhar, S. ; Venkat Reddy, M. (2000) Enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-Nebivolol Tetrahedron, 56 (34). pp. 6339-6344. ISSN 0040-4020

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/S0040-4020(00)00572-X

Abstract

The total synthesis of (S,R,R,R)-Nebivolol, a hypertensive agent, is reported. Claisen rearrangement and a one-pot Sharpless asymmetric epoxidation, intramolecular epoxide opening with internal phenoxide anion to generate the chiral chromane are the key steps.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Amine; Chromanes; Antihypertensive; Epoxidation; Coupling Reaction
ID Code:63503
Deposited On:29 Sep 2011 04:15
Last Modified:29 Sep 2011 04:15

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