Shah, Bhahwal Ali ; Chib, Renu ; Gupta, Pankaj ; Sethi, Vijay Kumar ; Koul, Surrinder ; Andotra, Samar Singh ; Nargotra, Amit ; Sharma, Sujata ; Pandey, Anjali ; Bani, Sarang ; Purnima, Basant ; Taneja, Subhash Chandra (2009) Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus Organic and Biomolecular Chemistry, 7 (16). pp. 3230-3235. ISSN 1477-0520
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Official URL: http://pubs.rsc.org/en/content/articlelanding/2009...
Related URL: http://dx.doi.org/10.1039/B902041A
Abstract
Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-α. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 63460 |
| Deposited On: | 29 Sep 2011 04:31 |
| Last Modified: | 29 Sep 2011 04:31 |
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