Bhatnagar, Nirupama Banerjee ; Bhatnagar, Rakesh ; Venkitasubramanian, Tathamangalam A. (1984) Characterization and metabolism of cyclic guanosine 3'5'-monophosphate in Mycobacterium sineginatis Biochemical and Biophysical Research Communications, 121 (2). pp. 634-640. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0006-291X(84)90229-8
Abstract
Cyclic guanosine 3'5'-monophosphate was isolated and purified from Mycobacterium sineginatis TMC 1515 using ion exchange chromatography. It was characterized by thin layer chromatography and radioimmunoassay. Guanylate cyclase and cGMP phosphodiesterase were detected in the cytosolic and particulate (37,000 ° g pellet) fractions respectively. On the basis of our observations, cGMP appears to play a dual role (i) at the time of induction of cell proliferation and (ii) protects the bacteria against unfavourable surroundings during stationary phase-of the growth. This is the first report demonstrating presence of cGMP, guanylate cyclase and cGMP phosphodiesterase in mycobacteria.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 63355 |
| Deposited On: | 28 Sep 2011 10:33 |
| Last Modified: | 28 Sep 2011 10:33 |
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