Singh, Aparna ; Singh, Samer ; Waheed, Syed Mohsin ; Khandelwal, Puneet ; Bhatnagar, Rakesh (2002) Expression of anthrax lethal factor gene by osmolyte induction FEMS Microbiology Letters, 209 (2). pp. 301-305. ISSN 0378-1097
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1574-...
Related URL: http://dx.doi.org/10.1111/j.1574-6968.2002.tb11148.x
Abstract
The anthrax toxin consists of protective antigen (PA), lethal factor (LF) and edema factor (EF). PA mediates the entry of LF and EF to the cytosol where they exert their effects. Although PA is the major component of the vaccines against anthrax, LF has also been found to play an important role in enhancing protective immunity. We have developed an osmolyte-inducible LF expression system. The protein expression system contributed no additional amino acids to the recombinant LF making it suitable for the human vaccine trials.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Anthrax; Lethal Factor; Osmolyte Induction |
| ID Code: | 63331 |
| Deposited On: | 28 Sep 2011 10:12 |
| Last Modified: | 28 Sep 2011 10:12 |
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