Chandrasekhar, S. ; Jagadeshwar, V. ; Narsihmulu, Ch. ; Sarangapani, M. ; Krishna, D. R. ; Vidyasagar, J. ; Vijay, Dolly ; Narahari Sastry, G. (2004) Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin Bioorganic & Medicinal Chemistry Letters, 14 (14). pp. 3687-3689. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2004.05.017
Abstract
A straight forward entry into nine membered B ring of eleutherobin as oxy analog and its cyctotoxic properties on HBL cell lines is described. Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of β-tubulin.The oxy-B-ring of eleutherobin skeleton 3 retains the binding affinity to tubulin receptor.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 63249 |
| Deposited On: | 28 Sep 2011 03:52 |
| Last Modified: | 28 Sep 2011 03:52 |
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