Mohapatra, Debendra K. ; Prem Kumar, B. ; Bhaskar, K. ; Yadav, Jhillu S. (2010) First total syntheses of (+)-garvensintriol and (+)-5-epi-garvensintriol Synlett, 2010 (7). pp. 1059-1062. ISSN 0936-5214
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Official URL: https://www.thieme-connect.com/ejournals/abstract/...
Related URL: http://dx.doi.org/10.1055/s-0029-1219557
Abstract
A concise and efficient carbohydrate-based approach for the total syntheses of (+)-garvensintriol and (+)-5-epi-garvensintriol is described in nine and six steps with 20% and 37% overall yield, respectively, starting from a known intermediate. A sequence of Grignard-assisted lactol opening with terminal alkyne, stereoselective keto reduction and oxidative lactonization are the key reactions.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers. |
| Keywords: | Garvensintriol; Goniotriol; Cytotoxic; Oxidative Lactonization; Grignard-assisted Lactol Opening |
| ID Code: | 63158 |
| Deposited On: | 28 Sep 2011 03:42 |
| Last Modified: | 28 Sep 2011 03:42 |
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