Studies directed towards the total synthesis of (−)-dictyostatin

Yadav, Jhillu S. ; Rajender, Vemula (2010) Studies directed towards the total synthesis of (−)-dictyostatin European Journal of Organic Chemistry, 2010 (11). pp. 2148-2156. ISSN 1434-193X

Full text not available from this repository.

Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ejoc.20...

Related URL: http://dx.doi.org/10.1002/ejoc.200901448

Abstract

The stereoselective synthesis of the three major fragments (C1-C9, C10-C17, and C19-C26) of an antimitotic marine macrolide, (−)-dictyostatin, has been achieved with a desymmetrization strategy and Oppolzer syn and anti aldol protocols as the key reactions. Takai olefination and Sonogashira coupling reactions were successfully utilized to establish the 2Z,4E-dienoate portion of the C1-C9 fragment and Stille coupling for the Z-diene core of C19-C26.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Aldol Reactions; Natural Products; Cross Coupling; Stereoselective Synthesis
ID Code:63155
Deposited On:28 Sep 2011 03:48
Last Modified:28 Sep 2011 03:48

Repository Staff Only: item control page