Synthesis of (+)-lycoricidine by the application of oxidative and regioselective ring-opening of aziridines

Abstract

A highly stereoselective total synthesis of (+)-lycoricidine has been described. The salient features of this synthesis are the one-pot elimination followed by allylation reaction, ring-closing metathesis, stereoselective aziridine formation, Dess-Martin periodinane, and silica gel mediated oxidative ring-opening of aziridine to form α,β-unsaturated ketone (allyl amine) and intramolecular Heck cyclization.