The concise synthesis of a key intermediate for the total synthesis of fumagillin, TNP-470, and ovalicin

Yadav, Jhillu S. ; Sreedhar, Pamu ; Srihari, Pabbaraja ; Dattatreya Sarma, Ganti ; Jagadeesh, Bharatam (2008) The concise synthesis of a key intermediate for the total synthesis of fumagillin, TNP-470, and ovalicin Synthesis, 2008 (9). pp. 1460-1466. ISSN 0039-7881

Full text not available from this repository.

Official URL: https://www.thieme-connect.com/ejournals/abstract/...

Related URL: http://dx.doi.org/10.1055/s-2008-1067030

Abstract

The facile synthesis of a key intermediate for the total synthesis of the antiangiogenic compound fumagillin, its semisynthetic analogue TNP-470, and ovalicin is described. The methodology employs a Diels-Alder strategy and a zinc-mediated ring-opening reaction to realize the cyclohexane backbone.

Item Type:Article
Source:Copyright of this article belongs to Thieme Medical Publishers.
Keywords:Angiogenesis Inhibitors; Diels-Alder Reaction; Syn Reduction; Dihydroxylation; HIV
ID Code:63063
Deposited On:28 Sep 2011 03:37
Last Modified:28 Sep 2011 03:37

Repository Staff Only: item control page